Journal article
Genetic Variations in SMAD7 Are Associated with Colorectal Cancer Risk in the Colon Cancer Family Registry
X Jiang, JE Castelao, D Vandenberg, A Carracedo, CM Redondo, DV Conti, JP Paredes Cotoré, JD Potter, PA Newcomb, MN Passarelli, MA Jenkins, JL Hopper, S Gallinger, L Le Marchand, ME Martínez, DJ Ahnen, JA Baron, NM Lindor, RW Haile, M Gago-Dominguez
Plos One | PUBLIC LIBRARY SCIENCE | Published : 2013
Abstract
Background: Recent genome-wide studies identified a risk locus for colorectal cancer at 18q21, which maps to the SMAD7 gene. Our objective was to confirm the association between SMAD7 SNPs and colorectal cancer risk in the multi-center Colon Cancer Family Registry. Materials and Methods: 23 tagging SNPs in the SMAD7 gene were genotyped among 1,592 population-based and 253 clinic-based families. The SNP-colorectal cancer associations were assessed in multivariable conditional logistic regression. Results: Among the population-based families, both SNPs rs12953717 (odds ratio, 1.29; 95% confidence interval, 1.12-1.49), and rs11874392 (odds ratio, 0.80; 95% confidence interval, 0.70-0.92) were a..
View full abstractRelated Projects (2)
Grants
Awarded by National Cancer Institute
Funding Acknowledgements
This work was supported by National Cancer Institute, National Institutes of Health, grant # 5R01CA114472-02 and RFA # CA-95-011 and through cooperative agreements with members of the Colon Cancer Family Registry and P.I.s: the Australasian Colorectal Cancer Family Registry (U01 CA097735); the University of Southern California Familial Colorectal Neoplasia Collaborative Group (U01 CA074799); the Mayo Clinic Cooperative Family Registry for Colon Cancer Studies (U01 CA074800); the Ontario Registry for Studies of Familial Colorectal Cancer (U01 CA074783); the Seattle Colorectal Cancer Family Registry (U01 CA074794); the University of Hawaii Colorectal Cancer Family Registry (U01 CA074806); the University of California, Irvine Informatics Center (U01 CA078296); FIS PI12/02125 Accion Estrategica de Salud del Instituto de Salud Carlos III; FIS Intrasalud (PS09/02368); and the Botin Foundation. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.